Retinoblastoma protein and simian virus 40-dependent immortalization of human fibroblasts
نویسندگان
چکیده
منابع مشابه
Simian virus 40 and the human mesothelium.
D tumor viruses have evolved to replicate, not to cause tumors. Their carcinogenic effect depends on the blocking of the lytic cycle and the ability of latently infected, potentially proliferative cells to escape immune surveillance. These conditions can be satisfied by accidental ‘‘experiments of nature’’ or by the artifices of laboratory experimentation. Potentially tumorigenic papovaviruses ...
متن کاملModification of simian virus 40 protein A.
The A protein of simian virus 40 is phosphorylated in both productive and transforming infection. The phosphorylated amino acid has been identified as serine and has been localized in a single tryptic peptide of the protein. Because the A protein synthesized in infection by A mutants is phosphorylated to the same extent and in the same peptide as in infection by wild-type virus, the functional ...
متن کاملSimian virus 40 and human disease.
Received 11 August 2004; accepted 11 August 2004; electronically published 16 November 2004. Reprints or correspondence: Dr. Keerti Shah, Dept. of Microbiology and Immunology, Johns Hopkins School of Public Health, 615 North Wolfe St., Baltimore, MD 21205 (kvshah @jhsph.edu). The Journal of Infectious Diseases 2004;190:2061–4 2004 by the Infectious Diseases Society of America. All rights reserv...
متن کاملSimian Virus 40 (SV40) and Human Cancers
Simian virus 40 (SV40) contaminated the early poliovirus vaccines used throughout much of the world during the late 1950’s and early 1960’s. SV40 is oncogenic in rodents and can transform human cells in vitro. Most epidemiologic studies, however, have failed to detect increased risks of cancer among those exposed to SV40-contaminated poliovirus vaccines, even after more than 30 years of follow-...
متن کاملSelective killing of simian virus 40-transformed human fibroblasts by parvovirus H-1.
A normal strain of human foreskin fibroblasts, two SV40-transformed derivatives with finite and infinite life spans, and an established line of SV40-transformed newborn human kidney cells are compared for their susceptibility to infection with parvovirus H-1. H-1 inocula, which do not detectably alter the growth of normal cells, cause a progressive degeneration of all three SV40-transformed cul...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1991
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.65.6.2845-2852.1991